Green approaches in medicinal chemistry for sustainable drug design [electronic resource] / edited by Bimal Krishna Banik.
- 其他作者:
- 出版: Amsterdam, Netherlands ;Cambridge, MA : Elsevier 2020.
- 叢書名: Advances in green and sustainable chemistry
- 主題: Pharmaceutical chemistry. , Green chemistry. , Drugs--Design. , Chemistry, Pharmaceutical. , Green Chemistry Technology. , Drug Design. , Drugs--Design. , Green chemistry. , Pharmaceutical chemistry. , Electronic books.
- ISBN: 0128175931 (electronic bk.) 、 9780128175934 (electronic bk.) 、 9780128175927 、 0128175923
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- 一般註:Includes bibliographical references and index. Intro -- Green Approaches in Medicinal Chemistry for Sustainable Drug Design -- Copyright -- Contents -- Contributors -- Editor's biography -- Preface -- Part One: Green chemistry -- Chapter 1: Green chemistry assisted synthesis of natural and synthetic compounds as anticancer agents -- 1.1. Introduction -- 1.2. Natural products as anticancer agents -- 1.3. Synthetic compounds as anticancer agents -- 1.4. Conclusion -- References -- Chapter 2: Antibacterial and antimicrobial coatings on metal substrates by cold spray technique: Present and future persp ... -- 2.1. Introduction 2.2. The need for the development of antibacterial and antimicrobial coatings -- 2.3. The coating techniques -- 2.4. Thermal spraying: Processes and techniques -- 2.5. Cold spray: The process and its advantages -- 2.6. Present status of the antibacterial and antimicrobial coating by cold spray -- 2.7. Sustainability and cold spray technique -- 2.8. Green aspects of cold spray -- 2.9. Future prospects and concluding remarks -- 2.10. Summary -- References -- Chapter 3: Graphene oxide nanosheets as sustainable carbocatalysts: Synthesis of medicinally important heterocycles -- 3.1. Introduction 3.2. Strategies for the synthesis of medicinally important heterocyclic scaffolds using GO and CMGs -- 3.2.1. Synthesis of substituted pyrroles and related heterocycles using GO nanosheets -- 3.2.2. Synthetic approaches for quinazoline derivatives -- 3.2.3. Multicomponent approach for the synthesis of substituted pyridine derivatives -- 3.2.4. Synthesis of benzothiazines, benzothiazoles, imidazoles, and benzimidazoles -- 3.2.5. Synthesis of functionalized quinoxalines -- 3.2.6. Synthesis of 4H-pyrans, coumarins, chromenes, flavones, and xanthenes -- 3.2.7. Synthesis of pyrimidones 3.2.8. Catalytic processes for the synthesis of 1,2,3-triazoles -- References -- Chapter 4: Sustainable green technologies for synthesis of potential drugs targeted toward tropical diseases -- 4.1. Introduction -- 4.2. Dose reduction through improved drug composition -- 4.3. Green dose setting -- 4.4. Reduction of cost through green chemistry -- 4.5. Green chemistry in ARV therapy -- 4.6. Green technology in malaria treatment -- 4.7. Conclusion -- References -- Chapter 5: Clay-mediated synthesis of biologically active molecules: Green and sustainable approaches -- 5.1. Introduction 5.1.1. Green and sustainable approach -- 5.1.1.1. Basic principles of green chemistry -- 5.1.1.2. Basic green methods for chemical synthesis -- Microwave-induced method -- Sonication method -- Biosynthetic method -- 5.1.2. Clay minerals -- 5.1.2.1. Classification of clay -- 5.2. Clay-mediated synthesis of biologically active molecules -- 5.2.1. Natural clay -- 5.2.2. Montmorillonite K-10 clay -- 5.2.3. Modified montmorillonite clay -- 5.2.4. Modified montmorillonite K-10 clay -- 5.2.5. Natural bentonite clay -- 5.2.6. Modified bentonite clay -- 5.2.7. Montmorillonite KSF clay 110年度臺灣學術電子書暨資料庫聯盟採購
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館藏資訊

Extensive experimentation and high failure rates are a well-recognised downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry reveals how medicinal and green chemistry can work together to directly address this issue. After providing essential context to the growth of green chemistry in relation to drug discovery in Part 1, the book goes on to identify a broad range of practical methods and synthesis techniques in Part 2. Part 3 reveals how medicinal chemistry techniques can be used to improve efficiency, mitigate failure and increase the environmental benignity of the entire drug discovery process, whilst Parts 4 and 5 discuss natural products and microwave-induced chemistry. Finally, the role of computers in drug discovery is explored in Part 6. Identifies novel and cost effective green medicinal chemistry approaches for improved efficiency and sustainability Reflects on techniques for a broad range of compounds and materials Highlights sustainable and green chemistry pathways for molecular synthesis